The Common Factor Between Gastroenterology, Dermatology and ENT/Allergy Diseases

Author: Dr. Robert Eisdorfer, Lynx.MD chief medical officer and co-founder

The Shared Language of Immunology

At first glance, Gastroenterology, Dermatology, and ENT/Allergy appear to have little in common. As a cornerstone of Lynx.MD’s data and analytics strategy, further explanation should be helpful.

People with seemingly unrelated diseases can have similar experiences because of one common factor: excessive type 2 inflammation, which in itself is part of a normal immune response to allergens and infections. However, when it goes into overdrive, it can contribute to inflammatory diseases such as asthma, atopic dermatitis (eczema), chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis (a chronic and progressive digestive disease), or even certain environmental allergies. Treatments directed at certain interleukins (ie. IL-12, IL-23 etc)work in a variety of disease states including:

• Asthma
• Atopic Dermatitis (AD) 
• Nasal Polyps (NP), or Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) 
• Eosinophilic Esophagitis (EoE) 
• Prurigo Nodularis (PN)
• Certain Food Allergies

Other types of inflammation result in diseases like IBD and psoriasis, and again treatments overlap specialty disciplines. 

From a real-world data (RWD) perspective, large data sets plus predictive analytics and machine learning should enable crucial insights. The correct drug at the right time and dose for each patient, and evaluation of response and natural history in people with more than one disease (ie. eosinophilic esophagitis and asthma). 

Large data sets have already provided insights into the natural history of crs with np, selection and dosing of biologics in different pt populations in IBD. Using LLM’s, images, and videos, along with longitudinal real world data will provide increased understanding of multiple inflammatory and immunologic diseases.

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About the Author

Dr. Robert Eisdorfer, Chief Medical Officer and co-founder of Lynx.MD is a Gastroenterology Specialist with over 38 years of experience in the medical field. He is passionate about advancing medicine and improving patient outcomes through the application of meaningful medical research and technology. Dr. Eisdorfer works with healthcare organizations around the world to provide strategic guidance for the consideration and adoption of new technology solutions.